Banach 3-Lie代数上两类映射的稳定性

结合函数方程pf(x+y/p+z)=f(x)+f(y)+pf(z),研究了Banach 3-Lie代数上的同态、导子以及广义导子的广义Hyers-Ulam稳定性(其中p为固定正整数).     

The Effectiveness of Structural Monetary Policy and Macro-Prudential Policies — Based on the DSGE Model That Includes Bank Heterogeneous Credit

Journal of Systems Science and Complexity - Structural monetary policy and macro-prudential policies are important parts of the policy system of the People’s Bank of China. By constructing a...     

企业现金持有水平对创新投入的影响研究基于现金保障天数的实证检验

目前我国新发展格局正在加速形成，企业需要抓住自主创新的机遇，因此一定水平的创新投入必不可少。然而，企业持有足够的现金是否能有效促进创新？本研究以2014~2019年我国A股上市公司为研究样本，首次使用企业的现金保障天数衡量现金持有水平，实证检验了现金持有水平与企业创新投入的关系。结论表明，现金持有水平能正向影响企业创新投入，且业绩波动性正向调节企业现金持有水平与创新投入之间的关系。异质性检验表明，非国有企业比国有企业现金持有水平对创新投入的促进作用更大，业绩波动性在非国有企业中调节效应更显著。企业可通过提高其现金保障天数来保证创新项目的资金投入，提高创新投入水平。     

基于知识图谱的核电设备健康管理知识建模与分析

随着信息技术发展,设备健康数据与知识图谱技术结合为设备健康发展带来新的发展机遇,知识图谱利用其多种特异性优势,使企业系统中积累的海量设备维修数据得到有效整合利用.本文提出基于知识图谱的核电设备健康管理知识建模与分析方法,并根据实体关系模型构建维修知识图谱本体框架,同时基于核电企业实际的维修工单数据,从统计分析和关联分析两方面取得良好的实践效果.研究结果表明,知识图谱能够在设备维修知识的集成上解决传统的数据孤岛问题,同时能基于故障的可视化分析为维修人员和管理人员提供决策和知识支持.     

自动驾驶汽车车底边框的优化算法

为了对通过YOLO框架所提取出的汽车底边框进行优化,首先对于道路上的每一辆汽车底部部分像素块建立改进后的高斯混合模型,通过该模型来刻画道路灰度值以及车底阴影灰度值的正态分布规律,然后通过对每辆检测到的汽车进行自上而下的扫描算法以确定汽车边框的实际高度,最后通过进行路测实验来说明算法的可行性与准确性.     

南京长江第四大桥钢箱梁铺装层温度影响系数分析

为了减少现有的钢桥面铺装层车辙深度预估的误差,提出基于长期实测数据的钢桥面铺装车辙评估模型的温度影响系数计算公式。首先对南京长江第四大桥的实测温度概率统计后采用双高斯函数表征其分布;在此基础上修正了现有车辙评估模型中的温度影响系数公式,并利用车辙实测数据对车辙评估模型计算值进行验证。研究结果表明:钢箱梁复合浇筑式铺装层温度可通过双高斯分布描述其概率分布;计入温度影响系数的车辙深度与实际车辙值之间误差较小,相对误差为15.2%。     

Molecular function of the novel α7β2 nicotinic receptor

The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional contribution of the β2 subunit, we generated heteromeric receptors with fixed stoichiometry by two different approaches comprising concatenated and unlinked subunits. Receptors containing up to three β2 subunits are functional. As the number of β2 subunits increases in the pentameric arrangement, the durations of channel openings and activation episodes increase progressively probably due to decreased desensitization. The prolonged activation episodes conform the kinetic signature of α7β2 and may have an impact on neuronal excitability. For activation of α7β2 receptors, an α7/α7 binding-site interface is required, thus indicating that the three β2 subunits are located consecutively in the pentameric arrangement. α7-positive allosteric modulators (PAMs) are emerging as novel therapeutic drugs. The presence of β2 in the pentamer affects neither type II PAM potentiation nor activation by an allosteric agonist whereas it impairs type I PAM potentiation. This first single-channel study provides fundamental basis required to decipher the role and function of the novel α7β2 receptor and opens doors to develop selective therapeutic drugs.     

Macropinocytosis,mTORC1 and cellular growth control

The growth and proliferation of metazoan cells are driven by cellular nutrient status and by extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical signals that increase anabolic metabolism and macropinocytosis, an actin-dependent endocytic process in which relatively large volumes of extracellular solutes and nutrients are internalized and delivered efficiently into lysosomes. Macropinocytosis is prominent in many kinds of cancer cells, and supports the growth of cells transformed by oncogenic K-Ras. Growth factor receptor signaling and the overall metabolic status of the cell are coordinated in the cytoplasm by the mechanistic target-of-rapamycin complex-1 (mTORC1), which positively regulates protein synthesis and negatively regulates molecular salvage pathways such as autophagy. mTORC1 is activated by two distinct Ras-related small GTPases, Rag and Rheb, which associate with lysosomal membranes inside the cell. Rag recruits mTORC1 to the lysosomal surface where Rheb directly binds to and activates mTORC1. Rag is activated by both lysosomal luminal and cytosolic amino acids; Rheb activation requires phosphoinositide 3-kinase, Akt, and the tuberous sclerosis complex-1/2. Signals for activation of Rag and Rheb converge at the lysosomal membrane, and several lines of evidence support the idea that growth factor-dependent endocytosis facilitates amino acid transfer into the lysosome leading to the activation of Rag. This review summarizes evidence that growth factor-stimulated macropinocytosis is essential for amino acid-dependent activation of mTORC1, and that increased solute accumulation by macropinocytosis in transformed cells supports unchecked cell growth.